Phagocytosis: Inflammation-Obesity Relationship

Obesity is a chronic, multifactorial disease with increasing worldwide prevalence. It characterized by excessive adipose tissue accumulation in the body, which decreases patient’s life expectancy and has been associated higher incidence of chronic degenerative diseases, including type 2 diabetes mellitus, systemic arterial hypertension, cancer, cardiovascular disease. Several investigations have found that obese humans rodents infiltrated high number macrophages. These cells interact apoptotic adipocytes, internalize accumulate lipids to become foam cells. processes lead release proinflammatory mediators promote insulin resistance. In addition, individuals obesity levels circulating neutrophils; however, these also infection, indicating phagocytic function affected. This chapter describes several studies could partly explain mechanisms affected obesity. Therapeutic alternatives favor capacity are discussed.